The cervix is the lower part of a woman’s womb or uterus. It is sometimes called the ‘Uterine Cervix’. The fetus grows in the body of the uterus which is the upper part. The cervix connects the body of the uterus to the vagina or birth canal. The part of the cervix closest to the body of the uterus is called the endocervix. The part next to the vagina is the exocervix or ectocervix. The 2 main types of cells covering the cervix are squamous cells (on the exocervix) and glandular cells (on the endocervix). These 2 cell types meet at a place called the transformation zone. Most cervical cancers starts in the transformation zone.
Most cervical cancers begin in the cells lining the cervix. These cells do not suddenly change into cancer. Instead, the normal cells of the cervix first gradually develop pre-cancerous changes that turn into cancer. Doctors use several terms to describe these pre-cancerous changes, including cervical intraepithelial neoplasia (CIN), squamous intraepithelial lesion (SIL), and dysplasia. These changes can be detected by the Pap test and treated to prevent cancer from developing.
http://www.cancer.org/cancer/cervicalcancer/detailedguide/cervical-cancer-what-is-cervical-cancer.
Gardasil, the new vaccine against human papilloma virus (HPV) -- which causes cervical cancer and genital warts.
Here is what you need to know now about this new vaccine.
1. What is Gardasil?
Gardasil is a vaccine, licensed for use in June 2006, by the FDA. It targets four strains of human papillomavirus (HPV) -- HPV-6, 11, 16, and 18. HPV-16 and HPV-18 account for about 70% of all cervical cancers. HPV-6 and -11 cause about 90% of genital warts. HPV is also linked to anal cancer.
2. How does HPV spread?
Sexual activity spreads the virus, a very common one. It's one of the most common sexually transmitted diseases (STDs) in the country, according to the CDC, with more than 20 million people currently infected and another 6.2 million contracting the virus each year.
About half of those with HPV are aged 15 to 24. Surveys suggest 3.7% of U.S. girls have sex by age 13, and 62.4% have had sex by the 12th grade.
3. Who should get the vaccine?
Gardasil is approved by the FDA for girls and women ages 9 to 26. The CDC and the American Academy of Pediatrics recommend that the vaccine be given routinely to girls at age 11 to 12 years old, although doctors may choose to vaccinate girls as young as 9. The CDC also recommends the vaccine for women age 13 to 26 who did not receive the vaccine at an earlier age.
However, if a girl or woman is already infected with HPV, the vaccine will not prevent that strain of HPV from causing disease. It will protect against new infections with other strains of HPV included in the vaccine.
The vaccine is also being studied in women up to age 45, although that group may be targeted for the vaccine later.
The vaccine is being studied in males, too. Men can get HPV infections and can pass the virus to their sex partners. HPV causes genital warts and is associated with rare cases of cancer of the penis. Particularly in gay men, HPV is linked to anal cancers. Merck is currently testing Gardasil in men, including gay men.
4. What is the best way to talk to my daughter about this?
Emphasize that the primary goal is to help prevent cervical cancer. If you, as a parent, are worried this will give your child a false sense of security that she can't catch a sexually transmitted infection from sexual activity, you can also emphasize that the vaccine only protects against certain strains of HPV -- not against any of the many other types of sexually transmitted infections.
5. Does Gardasil protect against all cervical cancers?
No. The vaccine does protect against the strains of HPV most likely to cause cancer. But it does not protect against all HPV strains.
However, recent reports suggest that the vaccine may give wider protection than originally thought. There is preliminary evidence it may offer some protection against other HPV strains, which cause 8% or 9% of cervical cancers.
6. How effective is the new vaccine?
Studies have shown it is 100% effective in the prevention of cervical precancers and noninvasive cervical cancers caused by HPV-16 and 18 in those not already exposed to those strains, according to Merck & Co. Inc., which makes Gardasil. Merck is a WebMD sponsor.
7. If someone is already sexually active, will this vaccine still work?
If a person has been infected with any of the four strains the vaccine protects against, the vaccine won't provide protection against that type. But it will prevent infection from the other three.
8. How long is Gardasil effective?
Research suggests the vaccine lasts at least four years. Long-term results are not yet certain. The protection might last longer.
9. Does the vaccine actually contain HPV or any live virus?
No. It has a virus-like particle, but not the actual virus.
10. Is Gardasil safe?
Clinical trial data have found it is safe.
11. How much will the vaccine cost?
Most doctors would charge you around 3,000+ Php per dose. Since the doses will be spread out up to 6 months, it is advisable that you save up around 10, 000+ Php to ensure your coverage for the three required doses of the cervical cancer vaccine.
12. Will the new vaccine make cervical cancer screens such as the Pap test passé?
No. Screening with a Pap test is still needed, since the vaccine does not protect against all cervical cancer.
13. Is this the only vaccine for cervical cancer?
There's a second vaccine in the works: Cervarix, from GlaxoSmithKline. Cervarix targets two HPV strains, HPV-16 and HPV-18. GSK says it plans to seek FDA approval for Cervarix by the end of the year. Early studies find that this vaccine, like Gardasil, is extremely safe and effective. GlaxoSmithKline is a WebMD sponsor.
15. How common is cervical cancer and how deadly?
The American Cancer Society predicts that in 2007, there will be about 11,150 new U.S. cases of invasive cervical cancer, and 3,670 cervical-cancer deaths.
Cervical cancer is the second most common cancer in women worldwide. There are about 500,000 new cases, and 250,000 cervical-cancer deaths each year. According to the World Health Organization, nearly 80% of cases occur in low-income countries, where cervical cancer is the most common cancer in women
16. Why are three doses of the cervical cancer vaccine needed?
Researchers don't yet know what antibody levels provide adequate protection from HPV. In early clinical trials, researchers observed that women's antibody levels continued to increase with each of the three doses of the vaccine. Since antibody levels inevitably fall once you stop getting a vaccine, it makes sense to start with high antibody levels and attempt to get the greatest HPV protection for the longest possible time — years or even decades.
17. Does the cervical cancer vaccine carry any health risks or side effects?
Overall, the effects are usually mild. The most common side effects of both HPV vaccines include soreness at the injection site (the upper arm), headaches, low-grade fever or flu-like symptoms. Sometimes dizziness or fainting occurs after the injection, especially in adolescents. Remaining seated for 15 minutes after the injection can reduce the risk of fainting. In addition, Cervarix may also cause nausea, vomiting, diarrhea or abdominal pain.
Serious side effects — including a severe allergic response (anaphylaxis), and neurological conditions, such as paralysis, weakness and brain swelling — have been reported in a small number of women. The FDA continues to monitor all such reports. To date, however, almost all reports of such adverse side effects appear to have occurred by chance around the time of immunization. They don't appear to have been caused by the vaccine itself.
18. What can you do to protect yourself from cervical cancer if you're not in the recommended vaccine age group?
HPV spreads through sexual contact. To protect yourself from HPV, use a condom every time you have sex and limit your number of sexual partners. In addition, don't smoke. Smoking doubles the risk of cervical cancer.
To detect cervical cancer in the earliest stages, see your health care provider for regular pelvic exams and Pap tests. Seek prompt medical attention if you notice any signs or symptoms of cervical cancer — vaginal bleeding after sex, between periods or after menopause, pelvic pain, or pain during sex.
19. Is the vaccine safe for pregnant woman?
The cervical cancer vaccine isn't recommended for pregnant women or people who are moderately or severely ill. Tell your doctor if you have any severe allergies, including an allergy to yeast or latex.
20. Does the cervical cancer vaccine offer benefits if you're already sexually active?
Yes. In clinical trials, Gardasil and Cervarix were effective in groups of sexually active women age 26 or younger, some of whom had already been infected with one or more types of HPV. However, Gardasil and Cervarix only protect you from specific strains of HPV to which you haven't been exposed. The more sexual partners you've had, the greater your chance of having been exposed to multiple types of HPV.
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We now know that this can be prevented. I am so happy that I am working in one of the best company in the US that is Philippine based which offers great benefits to their employees. Our health card includes FREE CERVICAL CANCER VACCINE. I will be getting 3 shots of the vaccine and this will start this coming Feb. 26th.
So sad though that I can’t divulge much of what me and my dear are getting from working in this company. I guess, mostly naman sa atin bawal gawin ata to e. Basta we are so lucky that we get to work sa company na to. Our Healt Card is… I should say ‘THE BEST’. Sssshhh lang ah… we even have derma or skin care benefits hehe
So sad though that I can’t divulge much of what me and my dear are getting from working in this company. I guess, mostly naman sa atin bawal gawin ata to e. Basta we are so lucky that we get to work sa company na to. Our Healt Card is… I should say ‘THE BEST’. Sssshhh lang ah… we even have derma or skin care benefits hehe
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